EVOREG - Evolution of regulations and control of biological cycles
Our team is interested in regulations at the level of the organism, their molecular mechanisms and their role in the control, evolution and adaptation of biological life cycles. Our goal is to understand the evolution of these regulations. We use multiple approaches dealing with different organizational and temporal levels: neuroendocrine regulations in so-called “non-conventional model species”, cellular and integrative physiology of the regulatory systems, development and phylogeny of regulatory systems.
In addition to this evolutionary point of view, we also integrate as far as possible ecological and ecophysiological data relative to the life cycle of these species (eco-evo-devo / eco-evo-endocrino approaches). Such an integrated approach allows a better understanding of past biological systems and their evolution on one hand, and hopefully comes to better predictions in terms of adaptive abilities of these biological systems on the other hand.
The “non conventional” biological models we use (molluscs: oyster, cuttlefish; non-mammalian vertebrates: migratory teleost and chondrichthyan) are chosen for their phylogenetic, ecological and/or socio-economical interest.
Our approach aims at an integrated comprehension of biological functions, in their ecological context and under the light of their historical contingency.
Our main research axes are
- Neuro-hormonal control of reproduction and other key steps of biological cycles (growth, metamorphosis, migrations)
Depending on the models and the current knowledge, we are interested in
- the characterization / deorphanisation of receptors
- the characterization of the neuroendocrine pathways controlling the biological cycle
- the evolution of these neuroendocrine pathways by genomic and phylogenetic approaches.
- Development and evolution of the systems allowing the perception and analysis of ecological inputs (light, temperature, salinity, gas content), especially of the cellular and molecular actors implicated in neuronal circuitry responsible for this perception.
- Adaptive and evolutive consequences of the plasticity of these biological control systems, particularly in response to induced environmental changes (including global warming)
Latest scientific articles
2021
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. 2021. “Effects Of Melatonin On Anterior Pituitary Plasticity: A Comparison Between Mammals And Teleosts”. Frontiers In Endocrinology 11. doi:10.3389/fendo.2020.605111. https://www.frontiersin.org/articles/10.3389/fendo.2020.605111/full.
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. 2021. “The Chicken And Egg Situation Of Thyroid Hormone And Glucocorticoid Signaling During Postembryonic Development”. Endocrinology 162 (3). doi:10.1210/endocr/bqaa243. https://academic.oup.com/endo/article/doi/10.1210/endocr/bqaa243/6054192.
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. 2021. “Dietary Taurine Improves Vision In Different Age Gilthead Sea Bream (Sparus Aurata) Larvae Potentially Contributing To Increased Prey Hunting Success And Growth”. Aquaculture 533: 736129. doi:10.1016/j.aquaculture.2020.736129. https://linkinghub.elsevier.com/retrieve/pii/S0044848620338357.
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. 2021. “Photoperiodic Regulation Of Pituitary Thyroid-Stimulating Hormone And Brain Deiodinase In Atlantic Salmon”. Molecular And Cellular Endocrinology 519: 111056. doi:10.1016/j.mce.2020.111056. https://linkinghub.elsevier.com/retrieve/pii/S0303720720303580.
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. 2021. “Melatonin And Osmoregulation In Fish: A Focus On Atlantic Salmon Salmo Salar Smoltification”. Journal Of Neuroendocrinology 33 (3). doi: https://doi.org/10.1111/jne.12955. https://onlinelibrary.wiley.com/toc/13652826/33/3.
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. 2021. “Molecular And Physiological Characterization Of A Crustacean Cardioactive Signaling System In A Lophotrochozoan - The Pacific Oyster (Crassostrea Gigas): A Role In Reproduction And Salinity Acclimation.”. J Exp Biol 224 (10). doi:10.1242/jeb.241588.
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. 2021. “Transcriptome Profiling Of The Pacific Oyster Visceral Ganglia Over A Reproduction Cycle Identifies Novel Regulatory Peptides.”. Mar Drugs 19 (8). doi:10.3390/md19080452.
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. 2021. “Special Features Of Neuroendocrine Interactions Between Stress And Reproduction In Teleosts”. General And Comparative Endocrinology 300: 113634. doi:10.1016/j.ygcen.2020.113634. https://linkinghub.elsevier.com/retrieve/pii/S0016648020303877.
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. 2021. “A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, And Early Development In The Pacific Oyster (Crassostrea Gigas)”. Marine Biotechnology. doi:10.1007/s10126-021-10052-5. https://link.springer.com/10.1007/s10126-021-10052-5.
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. 2021. “Molecular And Cellular Regulation On Sex Change In Hermaphroditic Fish, With A Special Focus On Protandrous Black Porgy, Acanthopagrus Schlegelii.”. Mol Cell Endocrinol 520: 111069. doi:10.1016/j.mce.2020.111069.
Gallery
Team members
PhD Thesis
Programs
| 2020 to 2023 | Yuschan Schoolar Program Taiwan |
| 2020 to 2023 | Yuschan Scholar Program Taiwan |
| 2020 to 2023 | Add-on Project |
| 2020 to 2022 | APOSTD 2020 |
| 2019 to 2021 | DIM1Health |
| 2019 to 2021 | UPSIDE |
| 2018 to 2021 | ECUME |
| 2019 to 2020 | PHC Finlay |
| 2015 to 2020 | MANCHE 2012 |
| 2020 | CADRES |
| 2015 to 2019 | NEMO |
| 2018 | JSPS 2018 LIGHTOME, France-Japon |
| 2018 | Peptides sécrétagogues de l’hormone de croissance chez les espèces d’intérêt aquacole : abord des effets neuroendocrines directs hypophysaires chez les téléostéens |
| 2015 to 2018 | IMPRESS |
| 2017 to 2018 | ATM LOCUS |
| 2013 to 2017 | ANR SalTemp |
| 2014 to 2017 | REPRO-TEMP France-Espagne |
| 2016 to 2017 | DEVO-LU puis LEDS |
| 2014 to 2017 | Global Networking Talent, MoST Taiwan |
| 2011 to 2016 | Alosa alosa |
| 2016 | DEVEOP (Picard+) |
| 2015 to 2016 | ATM SEPIOM |
| 2015 to 2016 | DYNA |
| 2013 to 2016 | COST AQUAGAMETE |
| 2014 to 2015 | MADREPOP |
| 2014 to 2015 | ATM CRISPR |
| 2010 to 2015 | PRO-EEL |
| 2010 to 2014 | ANR IMMORTEEL |
| 2014 | ATM PIGMENT |
| 2014 | ATM YEUX |