EVOREG - Evolution of regulations and control of biological cycles
Our team is interested in regulations at the level of the organism, their molecular mechanisms and their role in the control, evolution and adaptation of biological life cycles. Our goal is to understand the evolution of these regulations. We use multiple approaches dealing with different organizational and temporal levels: neuroendocrine regulations in so-called “non-conventional model species”, cellular and integrative physiology of the regulatory systems, development and phylogeny of regulatory systems.
In addition to this evolutionary point of view, we also integrate as far as possible ecological and ecophysiological data relative to the life cycle of these species (eco-evo-devo / eco-evo-endocrino approaches). Such an integrated approach allows a better understanding of past biological systems and their evolution on one hand, and hopefully comes to better predictions in terms of adaptive abilities of these biological systems on the other hand.
The “non conventional” biological models we use (molluscs: oyster, cuttlefish; non-mammalian vertebrates: migratory teleost and chondrichthyan) are chosen for their phylogenetic, ecological and/or socio-economical interest.
Our approach aims at an integrated comprehension of biological functions, in their ecological context and under the light of their historical contingency.
Our main research axes are
- Neuro-hormonal control of reproduction and other key steps of biological cycles (growth, metamorphosis, migrations)
Depending on the models and the current knowledge, we are interested in
- the characterization / deorphanisation of receptors
- the characterization of the neuroendocrine pathways controlling the biological cycle
- the evolution of these neuroendocrine pathways by genomic and phylogenetic approaches.
- Development and evolution of the systems allowing the perception and analysis of ecological inputs (light, temperature, salinity, gas content), especially of the cellular and molecular actors implicated in neuronal circuitry responsible for this perception.
- Adaptive and evolutive consequences of the plasticity of these biological control systems, particularly in response to induced environmental changes (including global warming)
Latest scientific articles
“K092A And K092B, Two Peptides Isolated From The Dogfish (Scyliorhinus Canicula L.), With Potential Antineoplastic Activity Against Human Prostate And Breast Cancer Cells”. Marine Drugs 17 (12): 672. doi:10.3390/md17120672. https://www.mdpi.com/1660-3397/17/12/672.. 2019.
“A Potential Antineoplastic Peptide Of Human Prostate Cancer Cells Derived From The Lesser Spotted Dogfish (Scyliorhinus Canicula L.)”. Marine Drugs 17 (10): 585. doi:10.3390/md17100585. https://www.mdpi.com/1660-3397/17/10/585.. 2019.
“Histone Methylation Participates In Gene Expression Control During The Early Development Of The Pacific Oyster .”. Genes (Basel) 10 (9). doi:10.3390/genes10090695.. 2019.
“Dmrt1 (Doublesex And Mab-3-Related Transcription Factor 1) Expression During Gonadal Development And Spermatogenesis In The Japanese Eel.”. General And Comparative Endocrinology 279: 154-163.. 2019.
“Activation Of The Brain-Pituitary-Gonadotropic Axis In The Black Porgy Acanthopagrus Schlegelii During Gonadal Differentiation And Testis Development And Effect Of Estradiol Treatment.”. General And Comparative Endocrinology 281: 17-29.. 2019.
“Characterization Of An Evolutionarily Conserved Calcitonin Signalling System In A Lophotrochozoan, The Pacific Oyster ().”. J Exp Biol 222 (Pt 13). doi:10.1242/jeb.201319.. 2019.
“Tachykinin-3 Genes And Peptides Characterized In A Basal Teleost, The European Eel: Evolutionary Perspective And Pituitary Role.”. Frontiers In Endocrinology 9: 304.. 2018.
“Differential Expression Of Gonadotropin And Estrogen Receptors And Oocyte Cytology During Follicular Maturation Associated With Egg Viability In European Eel (Anguilla Anguilla)”. Comparative Biochemistry And Physiology, Part A 221: 44-54. https://doi.org/10.1016/j.cbpa.2018.03.010.. 2018.
“Characterization Of A Tachykinin Signalling System In The Bivalve Mollusc Crassostrea Gigas”. General And Comparative Endocrinology 266: 110-118. doi:https://doi.org/10.1016/j.ygcen.2018.05.003.. 2018.
|2020 to 2023||Yuschan Schoolar Program Taiwan|
|2020 to 2023||Add-on Project|
|2020 to 2023||Yuschan Scholar Program Taiwan|
|2020 to 2022||APOSTD 2020|
|2019 to 2021||UPSIDE|
|2018 to 2021||ECUME|
|2019 to 2021||DIM1Health|
|2015 to 2020||MANCHE 2012|
|2019 to 2020||PHC Finlay|
|2015 to 2019||NEMO|
|2017 to 2018||ATM LOCUS|
|2018||JSPS 2018 LIGHTOME, France-Japon|
|2015 to 2018||IMPRESS|
|2018||Peptides sécrétagogues de l’hormone de croissance chez les espèces d’intérêt aquacole : abord des effets neuroendocrines directs hypophysaires chez les téléostéens|
|2014 to 2017||REPRO-TEMP France-Espagne|
|2013 to 2017||ANR SalTemp|
|2014 to 2017||Global Networking Talent, MoST Taiwan|
|2016 to 2017||DEVO-LU puis LEDS|
|2013 to 2016||COST AQUAGAMETE|
|2015 to 2016||ATM SEPIOM|
|2015 to 2016||DYNA|
|2011 to 2016||Alosa alosa|
|2014 to 2015||MADREPOP|
|2010 to 2015||PRO-EEL|
|2014 to 2015||ATM CRISPR|
|2010 to 2014||ANR IMMORTEEL|