@article {3784,
	title = {Characterization of chitinase-like proteins (Cg-Clp1 and Cg-Clp2) involved in immune defence of the mollusc Crassostrea gigas.},
	journal = {FEBS J},
	volume = {274},
	year = {2007},
	month = {2007 Jul},
	pages = {3646-54},
	abstract = {<p>Chitinase-like proteins have been identified in insects and mammals as nonenzymatic members of the glycoside hydrolase family 18. Recently, the first molluscan chitinase-like protein, named Crassostrea gigas (Cg)-Clp1, was shown to control the proliferation and synthesis of extracellular matrix components of mammalian chondrocytes. However, the precise physiological roles of Cg-Clp1 in oysters remain unknown. Here, we report the cloning and the characterization of a new chitinase-like protein (Cg-Clp2) from the oyster Crassostrea gigas. Gene expression profiles monitored by quantitative RT-PCR in adult tissues and through development support its involvement in tissue growth and remodelling. Both Cg-Clp1- and Cg-Clp2-encoding genes were transcriptionally stimulated in haemocytes in response to bacterial lipopolysaccharide challenge, strongly suggesting that these two close paralogous genes play a role in oyster immunity.</p>
},
	keywords = {Aging, Amino Acid Sequence, Animals, Chitinase, Crassostrea, DNA, Complementary, Gene Expression Regulation, Developmental, Hemocytes, Humans, Lipopolysaccharides, Molecular Sequence Data, RNA, Messenger, Sequence Alignment, Sequence Homology, Transcription, Genetic},
	issn = {1742-464X},
	doi = {10.1111/j.1742-4658.2007.05898.x},
	author = {Badariotti, Fabien and Christophe Lelong and Marie-Pierre Dubos and Pascal Favrel}
}
