@article {5166,
	title = {Bioaccumulation, distribution and elimination of chlordecone in the giant freshwater prawn Macrobrachium rosenbergii: Field and laboratory studies},
	journal = {Chemosphere},
	volume = {185},
	year = {2017},
	pages = {888 - 898},
	abstract = {<p>Abstract Chlordecone is a persistent organochlorine pesticide that has been widely used in Guadeloupe (French West Indies) to control the banana weevil Cosmopolites sordidus from 1972 to 1993. A few years after its introduction, widespread contamination of soils, rivers, wild animals and aquatic organisms was reported. Although high chlordecone concentrations have been reported in several crustacean species, its uptake, internal distribution, and elimination in aquatic species have never been described. This study aimed at investigating the accumulation and tissue distribution of chlordecone in the giant freshwater prawn Macrobrachium rosenbergii, using both laboratory (30 days exposure) and field (8 months exposure) approaches. In addition, depuration in chlordecone-free water was studied. Results showed that chlordecone bioconcentration in prawns was dose-dependent and time-dependent. Moreover, females appeared to be less contaminated than males after 5 and 7 months of exposure, probably due to successive spawning leading in the elimination of chlordecone through the eggs. Chlordecone distribution in tissues of exposed prawns showed that cephalothorax organs, mainly represented by the hepatopancreas, was the most contaminated. Results also showed that chlordecone was accumulated in cuticle, up to levels of 40\% of the chlordecone body burden, which could be considered as a depuration mechanism since chlordecone is eliminated with the exuviae during successive moults. Finally, this study underlined the similarity of results obtained in laboratory and field approaches, which highlights their complementarities in the chlordecone behaviour understanding in M.\&nbsp;rosenbergii.</p>
},
	keywords = {Bioaccumulation factor},
	issn = {0045-6535},
	doi = {https://doi.org/10.1016/j.chemosphere.2017.07.099},
	url = {http://www.sciencedirect.com/science/article/pii/S0045653517311529},
	author = {Anne Lafontaine and Eric Gismondi and Nathalie Dodet and C{\'e}lia Joaquim-Justo and C{\'e}line Boulang{\'e}-Lecomte and Fanny Caupos and Lemoine, Soazig and Laurent Lagadic and Jo{\"e}lle Forget-Leray and Jean-Pierre Thom{\'e}}
}
@article {4860,
	title = {Proteomic response of Macrobrachium rosenbergii hepatopancreas exposed to chlordecone: Identification of endocrine disruption biomarkers?},
	journal = {Ecotoxicology and Environmental Safety},
	volume = {141},
	year = {2017},
	pages = {306-314},
	author = {Lafontaine, Anne and Baiwir, Dominique and Joaquim-Justo, C{\'e}lia and de Pauw, Edwin and Lemoine, Soazig and Boulang{\'e}-Lecomte, C{\'e}line and Jo{\"e}lle Forget-Leray and Thom{\'e}, Jean-Pierre and Gismondi, Eric}
}
@article {4281,
	title = {Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii},
	journal = {Aquatic toxicology},
	year = {2016},
	abstract = {<p>Chlordecone (CLD) is an organochlorine insecticide abundant in aquatic environment of the French West Indies. However, few studies have investigated its impact on freshwater invertebrates. WhereasCLD is suspected of inducingendocrine disruption,this work aimed to study the effects of environmentally relevant concentrations of CLD on the 20-hydroxyecdysone (20-HE) hormone concentration and on the chitobiase activity, both having key roles in the molting process of crustaceans. In addition, the bioaccumulation of CLD was measured in the muscle tissueof Macrobrachium rosenbergiito underline potential dose-response relationship. The results have shown that CLD was bioaccumulated in exposed organisms according to a trend to a dose-response relationship. Moreover, it was observed that CLD decreased the 20-HE concentration in exposed prawns when compared to control, whatever the duration of exposure, as well as it inhibited the chitobiase activity after 30 days of exposure. The present study indicates that CLD could interfere with molting process of M. rosenbergiiby disturbing the 20-HE concentration and the activity of chitobiase, suggesting consequences at the long term on the shrimp development. This study also confirmed that CLD could be an endocrine disruptor in decapod crustaceans, as it was already observed in vertebrates.</p>
},
	keywords = {20-Hydroxyecdysone, Chitobiase, Chlordecone, Endocrine Disruptors, Macrobrachium rosenbergii},
	doi = {10.1016/j.aquatox.2016.04.006},
	author = {Lafontaine, Anne and Gismondi, Eric and Boulang{\'e}-Lecomte, C{\'e}line and Gerraudie, Perrine and Dodet, Nathalie and Campos, Fanny and Lemoine, Soazig and Lagadic, Laurent and Thom{\'e}, Jean-Pierre and Jo{\"e}lle Forget-Leray}
}
