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Guillaume RIVIERE

Guillaume RIVIERE's picture

Position

Assistant professor

Affiliation

Université de CAEN Normandie (UCN)

Email

guillaume.riviere@unicaen.fr

Phone

+33 2 31 56 51 13

Fax

+33 2 31 56 53 46

Localisation

Université de Caen Normandie (UCN)

Team

Team 2: Reproduction and development of aquatic organisms: evolution, adaptation, regulations

Research axis/workshop

Workshop Functional Genomics
Microinjection de CRISPR/Cas DNMT1 dans des stades embryonnaires précoces de C. gigas

Research topics

Epigenetic regulation and functional epigenomics of developemnt and reproduction in a marine invertebrate: understand the evolution of epigenetic mechanisms

How did epigenetic regulation, its molecular mechanisms and biological significance evolve ?

Is RNA methylation an evolutionary conserved vector of epitranscriptomic inheritance of environmental life traits ?

How can the development of organisms in a changing environment, which influences gene expression and chromatin structure, be so reproducible ?

What is the role of the nucleosome chemical modifications in the transient establishment of specific transcriptomes during cell differenciation ?

To contribute answering these questions, I try and understand the role of DNA (de-)methylation (5mC), RNA methylation (m6A-RNA), nucleosome chemical modifications and of their regulators in the development and reproduction in a distant model, the oyster Crassostrea gigas.  My research focuses on the description and understanding of epigenetic and epitranscriptomic mechanisms regulating gene expression/chromatin structure in cell differentiation during evolution. For this purpose I'm interested into the embryo development and reproduction (including triploïd oysters), i.e. processes underlied by an important cell differentiation in a context of a strong exposure/sensitivity to environmental parameters.

My benchwork is mostly based on molecular, cellular and biochemical approaches, including high throughput methodologies (MeDIP/BS/MeRIP-seq) as well as the development of functional studies (CRISPR/Cas).

Teaching

Animal biology, epigenetics, cell biology, developmental biology, evolution. 

Administrative responsibilities

Co-responsible Master Degree Biology and Health speciality Cancer, Différentiation, Genetics and Biotherapies ('CDG-Biother)

Co-responsible Research Master Degree Aquacaen

Responsible Teaching Unit Aqua 22 Master Aquacaen ‘Methodology- physiology of marine organisms’