Guillaume RIVIERE
Epigenetic regulation and functional epigenomics of developemnt and reproduction in a marine invertebrate: understand the evolution of epigenetic mechanisms
How did epigenetic regulation, its molecular mechanisms and biological significance evolve ?
Is RNA methylation an evolutionary conserved vector of epitranscriptomic inheritance of environmental life traits ?
How can the development of organisms in a changing environment, which influences gene expression and chromatin structure, be so reproducible ?
What is the role of the nucleosome chemical modifications in the transient establishment of specific transcriptomes during cell differenciation ?
To contribute answering these questions, I try and understand the role of DNA (de-)methylation (5mC), RNA methylation (m6A-RNA), nucleosome chemical modifications and of their regulators in the development and reproduction in a distant model, the oyster Crassostrea gigas. My research focuses on the description and understanding of epigenetic and epitranscriptomic mechanisms regulating gene expression/chromatin structure in cell differentiation during evolution. For this purpose I'm interested into the embryo development and reproduction (including triploïd oysters), i.e. processes underlied by an important cell differentiation in a context of a strong exposure/sensitivity to environmental parameters.
My benchwork is mostly based on molecular, cellular and biochemical approaches, including high throughput methodologies (MeDIP/BS/MeRIP-seq) as well as the development of functional studies (CRISPR/Cas).
Animal biology, epigenetics, cell biology, developmental biology, evolution.
Co-responsible Master Degree Biology and Health speciality Cancer, Différentiation, Genetics and Biotherapies ('CDG-Biother)
Co-responsible Research Master Degree Aquacaen
Responsible Teaching Unit Aqua 22 Master Aquacaen ‘Methodology- physiology of marine organisms’
Gallery
My Papers
2024
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. 2024. “Structural And Functional Characterization Of An Egg-Laying Hormone Signaling System In A Lophotrochozoan – The Pacific Oyster (Crassostrea Gigas)”. General And Comparative Endocrinology 346: 114417. doi:10.1016/j.ygcen.2023.114417. https://linkinghub.elsevier.com/retrieve/pii/S0016648023002228.
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. 2024. “Ancestors’ Gift: Parental Early Exposure To The Environmentally Realistic Pesticide Mixture Drives Offspring Phenotype In A Larger Extent Than Direct Exposure In The Pacific Oyster, Crassostrea Gigas”. Environmental Science & Technology. doi:10.1021/acs.est.3c0820110. https://pubs.acs.org/doi/10.1021/acs.est.3c08201.
2023
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. 2023. “M6A Profile Dynamics Indicates Regulation Of Oyster Development By M6A-Rna Epitranscriptomes”. Genomics, Proteomics & Bioinformatics 21 (4): 742 - 755. doi:10.1016/j.gpb.2022.12.002. https://linkinghub.elsevier.com/retrieve/pii/S1672022922001516.
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. 2023. “Molecular And Phenotypic Effects Of Early Exposure To An Environmentally Relevant Pesticide Mixture In The Pacific Oyster, Crassostrea Gigas.”. Environmental Pollution 326: 121472. doi:10.1016/j.envpol.2023.121472. https://linkinghub.elsevier.com/retrieve/pii/S0269749123004748.
2021
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. 2021. “Transcriptome Profiling Of The Pacific Oyster Crassostrea Gigas Visceral Ganglia Over A Reproduction Cycle Identifies Novel Regulatory Peptides”. Marine Drugs 19 (8): 452. doi:10.3390/md19080452. https://www.mdpi.com/1660-3397/19/8/452.
2020
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. 2020. “A Functional M6 A‐Rna Methylation Pathway In The Oyster Crassostrea Gigas Assumes Epitranscriptomic Regulation Of Lophotrochozoan Development”. The Febs Journal. doi:10.1111/febs.15500. https://onlinelibrary.wiley.com/doi/abs/10.1111/febs.15500.
febs.15500.pdf (1.47 MB)
2019
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. 2019. “Molecular Evolution And Functional Characterisation Of Insulin Related Peptides In Molluscs: Contributions Of Crassostrea Gigas Genomic And Transcriptomic-Wide Screening”. Journal Of Comparative Endocrinology 271: 15-29. Cherif_feildel 2019.pdf (4.32 MB)
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. 2019. “Histone Methylation Participates In Gene Expression Control During The Early Development Of The Pacific Oyster Crassostrea Gigas”. Genes 10 (9): 695. doi:10.3390/genes10090695. https://www.mdpi.com/2073-4425/10/9/695.
2018
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. 2018. “Copper Induces Expression And Methylation Changes Of Early Development Genes In Crassostrea Gigas Embryos”. Aquat Toxicol 196: 70-78. doi:doi: 10.1016/j.aquatox.2018.01.001. https://www.sciencedirect.com/science/article/pii/S0166445X18300018?via%3Dihub.
2017
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. 2017. “Dynamics Of Dna Methylomes Underlie Oyster Development”. Plos Genetics 13 (6): e1006807. https:// doi.org/10.13 71/journal.p gen.1006807. journal.pgen_.1006807.pdf (2.95 MB)
2015
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. 2015. “Regulation Of Hox Orthologues In The Oyster Crassostrea Gigas Evidences A Functional Role For Promoter Dna Methylation In An Invertebrate.”. Febs Lett 589 (13): 1459-66. doi:10.1016/j.febslet.2015.04.043. StCarlier_Riviere_FEBS2015.pdf (1.51 MB)
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. 2015. “Gigaton: An Extensive Publicly Searchable Database Providing A New Reference Transcriptome In The Pacific Oyster Crassostrea Gigas.”. Bmc Bioinformatics 16: 401. doi:10.1186/s12859-015-0833-4. GigaTON.pdf (3.09 MB)
2014
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. 2014. “Temperature Influences Histone Methylation And Mrna Expression Of The Jmj-C Histone-Demethylase Orthologues During The Early Development Of The Oyster Crassostrea Gigas.”. Mar Genomics. doi:10.1016/j.margen.2014.09.002.
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. 2014. “Epigenetic Features In The Oyster Crassostrea Gigas Suggestive Of Functionally Relevant Promoter Dna Methylation In Invertebrates.”. Frontiers In Physiology 5. doi:10.3389/fphys.2014.00129. fphys-05-00129.pdf (1.18 MB)
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. 2014. “The Jumonji Gene Family In Crassostrea Gigas Suggests Evolutionary Conservation Of Jmj-C Histone Demethylases Orthologues In The Oyster Gametogenesis And Development.”. Gene 538 (1): 164-75. doi:10.1016/j.gene.2013.12.016.