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CGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor

TitreCGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor
Type de publicationJournal Article
Year of Publication2006
AuteursCudennec, B, Rousseau, M, Lopez, E, Fouchereau-Peron, M
JournalPeptides
Volume27
Pagination2678–2682
ISSN0196-9781
Résumé

The physiological significance of calcitonin gene-related peptide (CGRP) during biomineralization was investigated by assessing the effect of human CGRP on the carbonic anhydrase activity in gill membranes of the pearl oyster, Pinctada margaritifera. Salmon CT and human CGRP were able to induce a 150% increase of the basal activity. No additive effect was observed suggesting that both activities are mediated by the same receptor. The CGRP-stimulated effect was specific as demonstrated by the inhibition produced by the CGRP antagonist, hCGRP8-37. So, CGRP by its specific action on gill carbonic anhydrase controls the calcification process, an ancient role both in invertebrates and non-mammalian vertebrates. (c) 2006 Elsevier Inc. All rights reserved.

DOI10.1016/j.peptides.2006.05.019