Symposium visio « Innate immunity in a biomineralized context: trade-offs or synergies? », 23 et 24 mars 2021
Symposium visio « Innate immunity in a biomineralized context: trade-offs or synergies? », 23 et 24 mars 2021
Un symposium en visio est organisé autour de la biominéralisation et de l'immunité innée les 23 et 24 mars 2021 « Innate immunity in a biomineralized context: trade-offs or synergies? » par Le Studium Loire Valley Institute for Advanced Studies.
Sophie Berland, ingénieure de recherche MNHN/BOREA, interviendra au cours de la session 5 consacrée à : 'Invertabrates (bivalves, snails)' et communiquera sur :
« Probing the mechanical properties and biochemical defence offered by shell matrix proteins in bivalves »
Co-authors : Dr Arul Marie1 , Dr Jaison Arivalagan2. 1 UMR 7245 CNRS/MNHN, Sorbonne Universités, Muséum national d’Histoire naturelle Paris, France, 2 Proteomics Center of Excellence, Northwestern University, Chicago, IL-60611, USA
Résumé : Calcium carbonate is paired up with shell matrix proteins in the suited organo-mineral outer shell in molluscs. Advanced knowledge in the shell proteome is achieved with the development of proteomics providing insights in the biological control of biomineralization at the shell side. Four bivalve species of distant kinship were subjected to proteomics for sequence and function pattern analysis of their retrieved shell matrix proteins. Domains ruling for calcification mechanisms, e.g. carbonic anhydrase, chitin binding and tyrosinase remained common in all the species signing sustained calcifying control proteins. Other shell proteins were fitted with functions beyond mineralization of which with relationship to immunity and especially the phenoloxid layers. The shell proteome was analysed with focus on the modulation of the shell proteins as a meaning of adaptive response to unbalanced conditions for shell calcification. Interestingly, proteins with immunity-related domains appeared modulated. Provided the hypothesis that the shells have embraced evenly aspects of inheritance and adaptive response, decrypting this molecular information is critical to understand the biomineralization adaptation demands and to identify calcifyers populations resilience as well.
