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Effects of subchronic exposure to glyphosate in juvenile oysters (Crassostrea gigas): From molecular to individual levels.

TitreEffects of subchronic exposure to glyphosate in juvenile oysters (Crassostrea gigas): From molecular to individual levels.
Type de publicationJournal Article
Year of Publication2015
AuteursMottier, A, Séguin, A, Devos, A, Le Pabic, C, Voiseux, C, Lebel, J-M, Serpentini, A, Fievet, B, Costil, K
JournalMar Pollut Bull
Date Published2014 Oct 30
ISSN1879-3363
Résumé

Glyphosate-based herbicides are extensively used and can be measured in aquatic ecosystems, including coastal waters. The effect of glyphosate on non-target organisms is an issue of worldwide concern. The aim of this study was to investigate the effects of subchronic exposure to glyphosate in juvenile oysters, Crassostrea gigas. Yearling oysters were exposed to three concentrations of glyphosate (0.1, 1 and 100μgL(-1)) for 56days. Various endpoints were studied, from the individual level (e.g., gametogenesis and tissue alterations) to the molecular level (mRNA quantification), including biochemical endpoints such as glutathione-S-transferase (GST) and catalase activities and malondialdehyde content. No mortality and growth occurred during the experiment, and individual biomarkers revealed only slight effects. The levels of gene expression significantly increased in oysters exposed to the highest glyphosate concentration (GST and metallothioneins) or to all concentrations (multi-xenobiotic resistance). These results suggested an activation of defence mechanisms at the molecular level.

DOI10.1016/j.marpolbul.2014.10.026
Alternate JournalMar. Pollut. Bull.
Identifiant (ID) PubMed25455786