Le prochain séminaire BOREA/AVIV se tiendra le jeudi 22 novembre 2018 de 12h30 à 14h00 dans l'amphithéâtre Rouelle, Bâtiment de la Baleine (derrière l'enclos des Walabis, Jardin des Plantes), au Muséum national d'histoire naturelle (Paris).
Nous vous attendons nombreux pour l'intervention de Dr Rebeca Martinez, Animal Biotechnology Division, Aquatic Biotechnology Department, Center for Genetic Engineering and Biotechnology, CIGB, La Havane, Cuba (rebeca.martinez @cigb.edu.cu).
Titre du séminaire: "In vitro and in vivo biological activity of growth hormone secretagogue peptides: studies in fishes, crustaceans and mammals"
Résumé :
Growth hormone (GH) synthetic secretagogues (GHS) are a family of peptide molecules, able to enhance GH release in vitro and in vivo. GHS bind to a receptor inducing calcium mobilization, GHS receptor (GHSR). Ghrelin is the endogenous peptide ligand of GHSR. GHS peptides obtained by chemical synthesis exert biological activities on growth, fatty acid profile and innate immune system of fish larvae. Similar results on growth and immune system have also been obtained in crustacean larvae using these molecules. The innate immune system of fish is considered the first line of defense against a broad spectrum of pathogens; GHS peptides modulate the gene expression of some important immune related genes. GHS also activate anti-viral innate immune response in mice, by increasing interferon and anti-viral proteins. Furthermore, In mice and fish, GHS are able to increase the antigen-specific antibody response, due to their immunomodulatory action. It is the first demonstration of GHS antiviral activity and ability to act as a molecular adjuvant to the immune response in fish and mammals.
Invitée par Sylvie Dufour, UMR BOREA, Dpt AVIV