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The Toll/NF-κB pathway in cuttlefish symbiotic accessory nidamental gland.

TitleThe Toll/NF-κB pathway in cuttlefish symbiotic accessory nidamental gland.
Publication TypeJournal Article
Year of Publication2015
AuthorsCornet, V, Henry, J, Corre, E, Le Corguille, G, Zatylny-Gaudin, C
JournalDev Comp Immunol
Volume53
Issue1
Pagination42-46
Date Published2015 Jul 2
ISSN1879-0089
Abstract

The female genital apparatus of decapod cephalopods contains a symbiotic accessory nidamental gland (ANG) that harbors bacterial symbionts. Although the ANG bacterial consortium is now well described, the impact of symbiosis on Sepia officinalis innate immunity pathways remains unknown. In silico analysis of the de novo transcriptome of ANG highlighted for the first time the existence of the NF-κB pathway in S. officinalis. Several signaling components were identified, i.e. five Toll-like receptors, eight signaling cascade features, and the immune response target gene iNOS, previously described as being involved in the initiation of bacterial symbiosis in a cephalopod gland. This work provides a first key for studying bacterial symbiosis and its impact on innate immunity in S. officinalis ANG.

DOI10.1016/j.dci.2015.06.016
Alternate JournalDev. Comp. Immunol.
PubMed ID26143243